Affiliations 

  • 1 Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
  • 2 Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, New York, United States of America
  • 3 Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
  • 4 Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
  • 5 Infectious Disease Research Portfolio, Strategy & Operations, Moderna, Boston, Massachusetts, United States of America
  • 6 Office of the Chief Scientist, National Institute of Allergy and Infectious Disease Integrated Research Facility, Fort Detrick, Maryland, United States of America
  • 7 Nonclinical Studies Unit, Boston University School of Medicine National Emerging Infectious Diseases Laboratories, Boston, Massachusetts, United States of America
PLoS One, 2022;17(2):e0263834.
PMID: 35143571 DOI: 10.1371/journal.pone.0263834

Abstract

Disease associated with Nipah virus infection causes a devastating and often fatal spectrum of syndromes predominated by both respiratory and neurologic conditions. Additionally, neurologic sequelae may manifest months to years later after virus exposure or apparent recovery. In the two decades since this disease emerged, much work has been completed in an attempt to understand the pathogenesis and facilitate development of medical countermeasures. Here we provide detailed organ system-specific pathologic findings following exposure of four African green monkeys to 2.41×105 pfu of the Malaysian strain of Nipah virus. Our results further substantiate the African green monkey as a model of human Nipah virus disease, by demonstrating both the respiratory and neurologic components of disease. Additionally, we demonstrate that a chronic phase of disease exists in this model, that may provide an important opportunity to study the enigmatic late onset and relapse encephalitis as it is described in human disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.