Multinational prospective cohort study over 18 years of the risk factors for ventilator-associated pneumonia in 9 Asian countries: INICC findings

Rosenthal VD 1 , Yin R 2 , Rodrigues C 3 , Myatra SN 4 , Divatia JV 4 , Biswas SK 4 Show all authors , Shrivastava AM 4 , Kharbanda M 5 , Nag B 5 , Mehta Y 6 , Sarma S 6 , Todi SK 7 , Bhattacharyya M 7 , Bhakta A 8 , Gan CS 8 , Low MSY 8 , Kushairi MBM 8 , Chuah SL 8 , Wang QY 8 , Chawla R 9 , Jain AC 9 , Kansal S 9 , Bali RK 9 , Arjun R 10 , Davaadagva N 9 , Bat-Erdene B 10 , Begzjav T 10 , Basri MNM 11 , Tai CW 11 , Lee PC 11 , Tang SF 12 , Sandhu K 13 , Badyal B 13 , Arora A 13 , Sengupta D 13 , Tao L 14 , Jin Z 2

Affiliations 

  • 1 Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, USA; International Nosocomial Infection Control Consortium (INICC) Foundation, Miami, USA. Electronic address: vdr21@med.miami.edu
  • 2 Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, USA
  • 3 Pd Hinduja National Hospital, and Medical Research Centre, Department of Microbiology, Mumbai, India
  • 4 Tata Memorial Hospital, Homi Bhabha National Institute, Department of Anesthesiology, Critical Care and Pain, Mumbai, India
  • 5 Desun Hospital, Department of Critical Care, Kolkata, India
  • 6 Medanta The Medicity, Department of Critical Care and Anesthesiology, Haryana, India
  • 7 Advanced Medicare Research Institute AMRI Hospitals, Department of Critical Care, Kolkata, India
  • 8 University Malaya Medical Centre, Department of Pediatric Intensive Care, Kuala Lumpur, Malaysia
  • 9 Indraprastha Apollo Hospitals, Department of Critical Care, New Delhi, India
  • 10 Kerala Institute of Med Sciences Health, Department of Critical Care, Trivandrum, India
  • 11 International Islamic University Malaysia, Department of Anesthesia and Critical Care, Kuantan Pahang, Malaysia
  • 12 Universiti Kebangsaan Malaysia Specialist Children's Hospital, Department of Critical Care, Kuala Lumpur, Malaysia
  • 13 Max Super Speciality Hospital Saket Delhi, Department of Critical Care, New Delhi, India
  • 14 Zhongshan Hospital, Fudan University, Department of Pneumonology, Shanghai, China
Am J Infect Control, 2023 Jul;51(7):751-757.
PMID: 36400318 DOI: 10.1016/j.ajic.2022.11.005

Abstract

BACKGROUND: Ventilator associated pneumonia (VAP) rates in Asia are several times above those of US. The objective of this study is to identify VAP risk factors.

METHODS: We conducted a prospective cohort study, between March 27, 2004 and November 2, 2022, in 279 ICUs of 95 hospitals in 44 cities in 9 Asian countries (China, India, Malaysia, Mongolia, Nepal, Pakistan, Philippines, Sri Lanka, Thailand, Vietnam).

RESULTS: 153,717 patients, followed during 892,996 patient-days, acquired 3,369 VAPs. We analyzed 10 independent variables. Using multiple logistic regression we identified following independent VAP RFs= Age, rising VAP risk 1% per year (aOR=1.01; 95%CI=1.00-1.01, P

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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