The impact of healthcare-associated infections on mortality in ICU: A prospective study in Asia, Africa, Eastern Europe, Latin America, and the Middle East

Rosenthal VD 1 , Yin R 2 , Lu Y 2 , Rodrigues C 3 , Myatra SN 4 , Kharbanda M 5 Show all authors , Valderrama-Beltran SL 6 , Mehta Y 7 , Daboor MA 8 , Todi SK 9 , Aguirre-Avalos G 10 , Guclu E 11 , Gan CS 12 , Jiménez-Alvarez LF 13 , Chawla R 14 , Hlinkova S 15 , Arjun R 16 , Agha HM 17 , Zuniga-Chavarria MA 18 , Davaadagva N 19 , Basri MNM 20 , Gomez-Nieto K 21 , Aguilar-de-Moros D 22 , Tai CW 23 , Sassoe-Gonzalez A 24 , Aguilar-Moreno LA 25 , Sandhu K 26 , Janc J 27 , Aleman-Bocanegra MC 28 , Yildizdas D 29 , Cano-Medina YA 30 , Villegas-Mota MI 31 , Omar AA 32 , Duszynska W 33 , BelKebir S 34 , El-Kholy AA 35 , Alkhawaja SA 36 , Florin GH 37 , Medeiros EA 38 , Tao L 39 , Memish ZA 40 , Jin Z 2

Affiliations 

  • 1 Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Fl, USA; International Nosocomial Infection Control Consortium Foundation, Miami, Fl, USA. Electronic address: victor_rosenthal@inicc.org
  • 2 Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Fl, USA
  • 3 Pd Hinduja National Hospital And Medical Research Centre, Mumbai, India
  • 4 Tata Memorial Hospital, Homi Bhabha Nacional Institute, Mumbai, India
  • 5 Desun Hospital, Kolkata, India
  • 6 Pontificia Universidad Javeriana Hospital Universitario San Ignacio, Bogota, Colombia
  • 7 Medanta The Medicity, Haryana, India
  • 8 King Hussein Cancer Center, Amman, Jordan
  • 9 Advanced Medicare Research Institute AMRI Hospitals, Kolkata, India
  • 10 Hospital Civil de Guadalajara Fray Antonio Alcalde. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico
  • 11 Sakarya University Training and Research Hospital, Sakarya, Turkey
  • 12 University Malaya Medical Centre, Kuala Lumpur, Malaysia
  • 13 Clinica Universitaria Colombia, Bogota, Colombia
  • 14 Indraprastha Apollo Hospitals, New Delhi, India
  • 15 Catholic University In Ruzomberok, Faculty Of Health, Central Military Hospital Ruzomberok, Ruzomberok, Slovakia
  • 16 Kerala Institute Of Med Sciences Health, Trivandrum, India
  • 17 Cairo University Specialized Pediatric Hospital, Cairo, Egypt
  • 18 Hospital Clinica Biblica, San Jose de Costa Rica, Costa Rica
  • 19 Intermed Hospital, Ulaanbaatar, Mongolia
  • 20 International Islamic University Malaysia, Kuantan Pahang, Malaysia
  • 21 Clinica Sebastian de Belalcazar, Cali, Colombia
  • 22 Hospital del Niño Dr José Renán Esquivel, Panama, Panama
  • 23 Universiti Kebangsaan Malaysia Specialist Children's Hospital, Kuala Lumpur, Malaysia
  • 24 Hospital Regional de Alta Especialidad Ixtapaluca, Ixtapaluca, Mexico
  • 25 Clinica Infantil Santa María del Lago, Bogota, Colombia
  • 26 Max Super Speciality Hospital Saket Delhi, New Delhi, India
  • 27 Department of Anesthesiology and Intensive Therapy, 4th Clinical Military Hospital with Polyclinic, Wroclaw, Poland
  • 28 Hospital San Jose TecSalud, Monterrey, Nuevo Leon, Mexico
  • 29 Cukurova University. Balcali Hospital, Adana, Turkey
  • 30 Instituto Del Corazon De Bucaramanga Sede Bogota, Bogota, Colombia
  • 31 Instituto Nacional de Perinatología, Mexico DF, Mexico
  • 32 Infection Control Directorate. Ministry of Health, Kuwait City, Kuwait
  • 33 Wroclaw Medical University. Department of Anesthesiology and Intensive Therapy, Wroclaw, Poland
  • 34 An Najah National University Hospital, Nablus, Palestine
  • 35 Dar Alfouad Hospital, 6th of October City., 6th of October City, Egypt
  • 36 Salmaniya Medical Center, Manama, Bahrain
  • 37 University of Medicine and Pharmacy Victor Babes Timisoara Emergency Clinical County Hospital Romania, Timisoara, Romania
  • 38 Hospital Sao Paulo, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • 39 Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
  • 40 King Saud Medical City, Riyadh, Kingdom of Saudi Arabia
Am J Infect Control, 2023 Jun;51(6):675-682.
PMID: 36075294 DOI: 10.1016/j.ajic.2022.08.024

Abstract

BACKGROUND: The International Nosocomial Infection Control Consortium has found a high ICU mortality rate. Our aim was to identify all-cause mortality risk factors in ICU-patients.

METHODS: Multinational, multicenter, prospective cohort study at 786 ICUs of 312 hospitals in 147 cities in 37 Latin American, Asian, African, Middle Eastern, and European countries.

RESULTS: Between 07/01/1998 and 02/12/2022, 300,827 patients, followed during 2,167,397 patient-days, acquired 21,371 HAIs. Following mortality risk factors were identified in multiple logistic regression: Central line-associated bloodstream infection (aOR:1.84; P

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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