Epidemiology, Management, and Outcomes of Sepsis in ICUs among Countries of Differing National Wealth across Asia

Li A 1 , Ling L 2 , Qin H 3 , Arabi YM 4 , Myatra SN 5 , Egi M 6 Show all authors , Kim JH 7 , Mat Nor MB 8 , Son DN 9 , Fang WF 10 , Wahyuprajitno B 11 , Hashmi M 12 , Faruq MO 13 , Patjanasoontorn B 14 , Al Bahrani MJ 15 , Shrestha BR 16 , Shrestha U 16 , Nafees KMK 17 , Sann KK 18 , Palo JEM 19 , Mendsaikhan N 20 , Konkayev A 21 , Detleuxay K 22 , Chan YH 23 , Du B 3 , Divatia JV 5 , Koh Y 24 , Gomersall CD 2 , Phua J 1

Affiliations 

  • 1 Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore
  • 2 Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
  • 3 State Key Laboratory of Complex, Severe and Rare Disease, Medical Intensive Care Unit, Peking Union Medical College Hospital, Beijing, China
  • 4 King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
  • 5 Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
  • 6 Department of Anesthesiology and Intensive Care Medicine, Kobe University Hospital, Kobe, Japan
  • 7 Department of Critical Care Medicine, Korea University Ansan Hospital, Ansan, South Korea
  • 8 International Islamic University Malaysia Medical Centre, Kuantan, Malaysia
  • 9 Critical Care Unit, Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam
  • 10 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
  • 11 Department of Anesthesiology and Reanimation, Faculty of Medicine - University of Airlangga, Intensive Care Unit, Dr. Soetomo General Hospital, Surabaya, Indonesia
  • 12 Department of Anaesthesiology, Aga Khan University, Karachi, Pakistan
  • 13 General Intensive Care Unit and Emergency Department, United Hospital Ltd., Dhaka, Bangladesh
  • 14 Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • 15 Department of Anesthesia and Critical Care, Royal Hospital, Muscat, Oman
  • 16 Department of Anesthesia and Intensive Care, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal
  • 17 Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 18 Department of Anaesthesiology and Intensive Care Unit, Yangon General Hospital, University of Medicine 1, Yangon, Myanmar
  • 19 Acute and Critical Care Institute, The Medical City, Pasig City, Philippines
  • 20 Anaesthesia and Critical Care Department, Mongolian National University of Health Science, Ulaanbaatar, Mongolia
  • 21 Anaesthesiology and Intensive Care Department, Astana Medical University, Nur-Sultan, Kazakhstan
  • 22 Adult Intensive Care Unit, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
  • 23 Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • 24 Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; and
Am J Respir Crit Care Med, 2022 Nov 01;206(9):1107-1116.
PMID: 35763381 DOI: 10.1164/rccm.202112-2743OC

Abstract

Rationale: Directly comparative data on sepsis epidemiology and sepsis bundle implementation in countries of differing national wealth remain sparse. Objectives: To evaluate across countries/regions of differing income status in Asia 1) the prevalence, causes, and outcomes of sepsis as a reason for ICU admission and 2) sepsis bundle (antibiotic administration, blood culture, and lactate measurement) compliance and its association with hospital mortality. Methods: A prospective point prevalence study was conducted among 386 adult ICUs from 22 Asian countries/regions. Adult ICU participants admitted for sepsis on four separate days (representing the seasons of 2019) were recruited. Measurements and Main Results: The overall prevalence of sepsis in ICUs was 22.4% (20.9%, 24.5%, and 21.3% in low-income countries/regions [LICs]/lower middle-income countries/regions [LMICs], upper middle-income countries/regions, and high-income countries/regions [HICs], respectively; P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications