Nutraceuticals and COVID-19: A mechanistic approach toward attenuating the disease complications

Paudel KR 1 , Patel V 2 , Vishwas S 3 , Gupta S 4 , Sharma S 4 , Chan Y 5 Show all authors , Jha NK 6 , Shrestha J 7 , Imran M 8 , Panth N 1 , Shukla SD 2 , Jha SK 9 , Devkota HP 10 , Warkiani ME 7 , Singh SK 11 , Ali MK 12 , Gupta G 13 , Chellappan DK 5 , Hansbro PM 1 , Dua K 2

Affiliations 

  • 1 Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia
  • 2 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, New South Wales, Australia
  • 3 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India
  • 4 Delhi Pharmaceutical Sciences and Research University, New Delhi, India
  • 5 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
  • 6 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Nioda, India
  • 7 School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia
  • 8 Therapeutics Research Group, The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia
  • 9 Department of Biomedicine, Health and Life Convergence Sciences, Biomedical and Healthcare Research Institute, Mokpo National University, Muan, Korea
  • 10 Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • 11 Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, New South Wales, Australia
  • 12 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, California, USA
  • 13 School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India
J Food Biochem, 2022 Dec;46(12):e14445.
PMID: 36239436 DOI: 10.1111/jfbc.14445

Abstract

Nutraceuticals have emerged as potential compounds to attenuate the COVID-19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access. Therefore, current research is focused on developing newer advanced formulations from potential drug candidates including nutraceuticals with desirable properties viz, affordability, ease of availability, ease of administration, stability under room temperature, and potentially longer shelf-lives. As such, various nutraceutical-based products such as compounds could be promising agents for effectively managing COVID-19 symptoms and complications. Most importantly, regular consumption of such nutraceuticals has been shown to boost the immune system and prevent viral infections. Nutraceuticals such as vitamins, amino acids, flavonoids like curcumin, and probiotics have been studied for their role in the prevention of COVID-19 symptoms such as fever, pain, malaise, and dry cough. In this review, we have critically reviewed the potential of various nutraceutical-based therapeutics for the management of COVID-19. We searched the information relevant to our topic from search engines such as PubMed and Scopus using COVID-19, nutraceuticals, probiotics, and vitamins as a keyword. Any scientific literature published in a language other than English was excluded. PRACTICAL APPLICATIONS: Nutraceuticals possess both nutritional values and medicinal properties. They can aid in the prevention and treatment of diseases, as well as promote physical health and the immune system, normalizing body functions, and improving longevity. Recently, nutraceuticals such as probiotics, vitamins, polyunsaturated fatty acids, trace minerals, and medicinal plants have attracted considerable attention and are widely regarded as potential alternatives to current therapeutic options for the effective management of various diseases, including COVID-19.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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