Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam VSRR 1 , Chellappan DK 2 , Jha NK 3 , Shastri MD 4 , Gupta G 5 , Shukla SD 6 Show all authors , Singh SK 7 , Sunkara K 8 , Chitranshi N 9 , Gupta V 9 , Wich PR 10 , MacLoughlin R 11 , Oliver BGG 12 , Wernersson S 13 , Pejler G 1 , Dua K 14

Affiliations 

  • 1 Department of Medical Biochemistry and Microbiology, Biomedical Centre (BMC), Uppsala University, Uppsala, Sweden
  • 2 Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia
  • 3 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, India
  • 4 School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
  • 5 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India
  • 6 Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, New South Wales, Australia
  • 7 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
  • 8 Emergency Clinical Management, Intensive Care Unit, John Hunter Hospital, Newcastle, New South Wales, Australia
  • 9 Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, New South Wales, Australia
  • 10 School of Chemical Engineering, University of New South Wales, Sydney, New South Wales, Australia
  • 11 Aerogen, IDA Business Park, Dangan, Galway, Ireland
  • 12 School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia
  • 13 Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • 14 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia
Crit Rev Food Sci Nutr, 2021 May 12.
PMID: 33977840 DOI: 10.1080/10408398.2021.1915744

Abstract

Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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