• 1 Department of Chemistry, Faculty of Science, University of Malaya , 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2014 Jun 27;77(6):1532-5.
PMID: 24832351 DOI: 10.1021/np500289t


Racemic andransinine (1), an indole alkaloid derivative obtained during isolation of alkaloids from Alstonia angustiloba and Kopsia pauciflora, was found to undergo spontaneous resolution when crystallized in EtOAc, forming racemic conglomerates (an equimolar mechanical mixture of enantiomerically pure individual crystals). X-ray analyses of the enantiomers (obtained from crystals from EtOAc solution and from chiral-phase HPLC) provided the absolute configuration of each enantiomer as (15R,16S,21R)-(+)-andransinine (1a or I+) and (15S,16R,21S)-(-)-andransinine (1b or I-).

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