Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University of Malaya , 50603 Kuala Lumpur, Malaysia
Org. Lett., 2013 Sep 20;15(18):4774-7.
PMID: 23991636 DOI: 10.1021/ol4021404

Abstract

Two new indole alkaloids, voatinggine (1) and tabertinggine (2), which are characterized by previously unencountered natural product skeletons, were isolated from a Malayan Tabernaemontana species. The structures and absolute configuration of these alkaloids were determined using NMR and MS analysis, and X-ray diffraction analysis. A possible biogenetic pathway to these novel alkaloids from an iboga precursor, and via a common cleavamine-type intermediate, is presented.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.