Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon-Nitrogen Skeleton Derived from a Pericine Precursor

Wong SP 1 , Gan CY 2 , Lim KH , Ting KN , Low YY 1 , Kam TS 1

Affiliations 

  • 1 †Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 ‡University Malaysia of Computer Science and Engineering, Jalan Alamanda 2, Precint 1, 62000 Putrajaya, Malaysia
Org. Lett., 2015 Jul 17;17(14):3628-31.
PMID: 26183592 DOI: 10.1021/acs.orglett.5b01757

Abstract

A new monoterpene indole alkaloid characterized by an unprecedented pentacyclic cage skeleton, arboridinine (1), was isolated from a Malaysian Kopsia species. The structure and absolute configuration of the alkaloid were determined based on NMR, MS, and X-ray diffraction analysis. A possible biogenetic pathway from a pericine precursor is presented.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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