Fulltext

Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region-A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network

Reid CM 1 , Chih H 2 , Duffy SJ 3 , Brennan AL 4 , Ajani AE 5 , Beltrame J 6 Show all authors , Tavella R 6 , Yan BP 7 , Dinh D 4 , Chin CT 8 , Do LD 9 , Nguyen QN 9 , Nguyen HTT 9 , Wijaya IP 10 , Yamin M 10 , Rusdi L 10 , Alwi I 10 , Sim KH 11 , Yip Fong AY 11 , Wan Ahmad WA 12 , Yeo KK 8 , ASPECT Investigators

Affiliations 

  • 1 School of Population Health, Curtin University, Perth, WA, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia. Electronic address: christopher.reid@curtin.edu.au
  • 2 School of Population Health, Curtin University, Perth, WA, Australia
  • 3 School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia; Department of Cardiology, Alfred Health, Melbourne, Vic, Australia
  • 4 School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia
  • 5 School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia; Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Vic, Australia
  • 6 Discipline of Medicine, The University of Adelaide, Adelaide, SA, Australia
  • 7 Division of Cardiology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong SAR, China
  • 8 National Heart Centre Singapore, Singapore; Duke-NUS Medical School, Singapore
  • 9 Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam
  • 10 Cipto Mangunkusumo National General Hospital, Universitas Indonesia Medical School, Jalan Pangeran Diponegoro, Jakarta, Indonesia
  • 11 Sarawak Heart Centre, Sarawak, Malaysia; National Heart Association of Malaysia, Kuala Lumpur, Malaysia
  • 12 National Heart Association of Malaysia, Kuala Lumpur, Malaysia; University of Malaya Medical Centre, Jalan Universiti, Selangor, Malaysia
Heart Lung Circ, 2023 Feb;32(2):166-174.
PMID: 36272954 DOI: 10.1016/j.hlc.2022.08.012

Abstract

OBJECTIVE: The Asia-Pacific Evaluation of Cardiovascular Therapies (ASPECT) collaboration was established to inform on percutaneous coronary intervention (PCI) in the Asia-Pacific Region. Our aims were to (i) determine the operational requirements to assemble an international individual patient dataset and validate the processes of governance, data quality and data security, and subsequently (ii) describe the characteristics and outcomes for ST-elevation myocardial infarction (STEMI) patients undergoing PCI in the ASPECT registry.

METHODS: Seven (7) ASPECT members were approached to provide a harmonised anonymised dataset from their local registry. Patient characteristics were summarised and associations between the characteristics and in-hospital outcomes for STEMI patients were analysed.

RESULTS: Six (6) participating sites (86%) provided governance approvals for the collation of individual anonymised patient data from 2015 to 2017. Five (5) sites (83%) provided >90% of agreed data elements and 68% of the collated elements had <10% missingness. From the registry (n=12,620), 84% were male. The mean age was 59.2±12.3 years. The Malaysian cohort had a high prevalence of previous myocardial infarction (34%), almost twice that of any other sites (p<0.001). Adverse in-hospital outcomes were the lowest in Hong Kong whilst in-hospital mortality varied from 2.7% in Vietnam to 7.9% in Singapore.

CONCLUSIONS: Governance approvals for the collation of individual patient anonymised data was achieved with a high level of data alignment. Secure data transfer process and repository were established. Patient characteristics and presentation varied significantly across the Asia-Pacific region with this likely to be a major predictor of variations in the clinical outcomes observed across the region.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications