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Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

Ibrahim MY 1 , Hashim NM 2 , Omer FAA 3 , Abubakar MS 4 , Mohammed HA 5 , Salama SM 6 Show all authors , Jayash SN 7

Affiliations 

  • 1 Faculty of Pharmacy, Elrazi University, Khartoum 11115, Sudan
  • 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti of Malaya, Kuala Lumpur 50603, Malaysia
  • 3 Department of Chemistry and Biology, Faculty of Education-Hantoub, University of Gezira, Wad Madani 21111, Sudan
  • 4 Department of Veterinary Pathology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto 840212, Nigeria
  • 5 Faculty of Pharmacy, University of Sinnar, Sinja 25511, Sudan
  • 6 Indigenous Knowledge and Heritage Center, Ghibaish College of Science and Technology, Sinja 25511, Sudan
  • 7 School of Dentistry, University of Birmingham, 5 Mill Pool Way, Edgbaston, Birmingham B5 7EG, UK
Int J Mol Sci, 2023 Jun 17;24(12).
PMID: 37373429 DOI: 10.3390/ijms241210283

Abstract

In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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