• 1 Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College Hammersmith Campus, London, W12 ONN, UK; School of Chemical Sciences & Food Technology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600, Bangi Selangor, Malaysia
Obesity (Silver Spring), 2014 Jun;22(6):1430-8.
PMID: 24715424 DOI: 10.1002/oby.20754


OBJECTIVE: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.

METHODS: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.

RESULTS: Oligofructose increased breath hydrogen (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.