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Common driver mutations and programmed death-ligand 1 expression in advanced non-small cell lung cancer in smokers and never smokers

Liam CK 1 , Yew CY 2 , Pang YK 3 , Wong CK 3 , Poh ME 3 , Tan JL 2 Show all authors , Soo CI 3 , Loh TC 3 , Chin KK 3 , Munusamy V 2 , Liam YS 4 , Ibrahim NH 3

Affiliations 

  • 1 Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. liamck@ummc.edu.my
  • 2 Department of Medicine, University of Malaya Medical Centre, 59100, Kuala Lumpur, Malaysia
  • 3 Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Clinical Investigation Centre, University of Malaya Medical Centre, 59100, Kuala Lumpur, Malaysia
BMC Cancer, 2023 Jul 14;23(1):659.
PMID: 37452277 DOI: 10.1186/s12885-023-11156-y

Abstract

BACKGROUND: In non-small cell lung cancer (NSCLC), there may be a relationship between programmed death-ligand 1 (PD-L1) expression, driver mutations and cigarette smoking.

METHODS: In this single-center retrospective study, the relationship between common driver mutations (EGFR mutation and ALK rearrangement) and PD-L1 expression in advanced NSCLC according to the patients' smoking history was examined. Light, moderate and heavy smokers had smoked 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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