Affiliations 

  • 1 Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Faisalabad, Faisalabad 38000, Pakistan
  • 2 Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan
  • 3 Institute of Home & Food Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan
  • 4 Department of Pharmacy, University of Agriculture, Faisalabad 38000, Pakistan
  • 5 Quality Operations Laboratory, Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan
  • 6 Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore 53700, Pakistan
  • 7 Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Malaysia
Molecules, 2023 Jul 17;28(14).
PMID: 37513325 DOI: 10.3390/molecules28145453

Abstract

Diabetes mellitus is a chronic metabolic disorder defined as hyperglycemia and pancreatic β-cell deterioration, leading to other complications such as cardiomyopathy. The current study assessed the therapeutic effects of phenolic acids extracted from Jasminum sambac phenols of leaves (JSP) against diabetes-induced cardiomyopathy in rats. The rats were divided into four groups, with each group consisting of 20 rats. The rats were given intraperitoneal injections of alloxan monohydrate (150 mg/kg) to induce diabetes. The diabetes-induced groups (III and IV) received treatment for six weeks that included 250 and 500 mg/kg of JSP extract, respectively. In the treated rats, the results demonstrated that JSP extract restored fasting glucose, serum glucose, and hyperlipidemia. Alloxan induced cardiomyopathy, promoted oxidative stress, and altered cardiac function biomarkers, including cardiac troponin I, proBNP, CK-MB, LDH, and IMA. The JSP extract-treated rats showed improved cardiac function indicators, apoptosis, and oxidative stress. In diabetic rats, the mRNA expression of caspase-3, BAX, and Bcl-2 was significantly higher, while Bcl-2, Nrf-2, and HO-,1 was significantly lower. In the treated groups, the expression levels of the BAX, Nrf-2, HO-1, Caspase-3, and Bcl-2 genes were dramatically returned to normal level. According to our findings, the JSP extract prevented cardiomyopathy and heart failure in the hyperglycemic rats by improving cardiac biomarkers and lowering the levels of hyperlipidemia, oxidative stress, apoptosis, hyperglycemia, and hyperlipidemia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.