Fe2+ and Cu2+ increase the production of hyaluronic acid by lactobacilli via affecting different stages of the pentose phosphate pathway

Choi SB 1 , Lew LC , Hor KC , Liong MT

Affiliations 

  • 1 School of Industrial Technology, Universiti Sains Malaysia (USM), 11800, Penang, Malaysia
Appl Biochem Biotechnol, 2014 May;173(1):129-42.
PMID: 24648139 DOI: 10.1007/s12010-014-0822-5

Abstract

This study aimed at optimizing the production of hyaluronic acid by Lactobacillus acidophilus FTDC 1231 using response surface methodology and evaluating the effects of divalent metal ions along the production pathway using molecular docking. Among different divalent metal ions that were screened, only iron (II) sulphate and copper (II) sulphate significantly (P 

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