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The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis

Rehman AU 1 , Khattak M 1 , Mushtaq U 2 , Latif M 3 , Ahmad I 4 , Rasool MF 1 Show all authors , Shakeel S 5 , Hayat K 6 , Hussain R 7 , Alhazmi GA 8 , Alshomrani AO 9 , Alalawi MI 10 , Alghamdi S 11 , Imam MT 12 , Almarzoky Abuhussain SS 13 , Khayyat SM 13 , Haseeb A 13

Affiliations 

  • 1 Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • 2 Nishter Medical University and Hospital, Multan, Pakistan
  • 3 Department of Zoology, Division of Science and Technology, University of Education Lahore, Lahore, Pakistan
  • 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • 5 Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
  • 6 Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan
  • 7 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 8 Department of Pharmacy, King Abdullah Medical City, Ministry of Health, Makkah, Saudi Arabia
  • 9 Pharmaceutical Care Department, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia
  • 10 Internal Medicine Department, Alnoor Specialist Hospital, Makkah, Saudi Arabia
  • 11 Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia
  • 12 Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia
  • 13 Department of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
Front Public Health, 2023;11:1244450.
PMID: 38074769 DOI: 10.3389/fpubh.2023.1244450

Abstract

BACKGROUND: The existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression.

AIM: To investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients.

METHODOLOGY: The PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process.

RESULTS: Tuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60-0.96, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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