Affiliations 

  • 1 Nanotechnology and Catalysis Research Centre (NANOCAT), Institute for Advanced Studies (IAS), University of Malaya (UM), 50603, Kuala Lumpur, Malaysia
  • 2 Department of Chemical Engineering, National Taiwan University of Science and Technology, Taiwan
  • 3 Mechanical Engineering Department, College of Engineering, King Khalid University, Abha, 61421, Saudi Arabia
  • 4 Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia
  • 5 Harper Elite Sdn Bhd, UG-23, PJ Midtown, Jalan Kemajuan, Seksyen 13, 46200, Petaling Jaya, Selangor Darul Ehsan, Malaysia
Heliyon, 2024 Apr 15;10(7):e28902.
PMID: 38633652 DOI: 10.1016/j.heliyon.2024.e28902

Abstract

Rhodanine is a heterocyclic organic compound that has been investigated for its potential biomedical applications, particularly in drug discovery. Rhodanine derivatives have been examined as the medication options for numerous illnesses, including cancer, inflammation, and infectious diseases. Some rhodanine derivatives have also shown promising activity against drug-resistant strains of bacteria and viruses. One of these derivatives is polyrhodanine (PR), a conducting polymer that has gained attention for its biomedical properties. This review article summarises the latest advancements in creating biomaterials based on PR for biosensing, antimicrobial treatments, and anticancer therapies. The distinctive characteristics of PR, such as biocompatibility, biodegradability, and good conductivity, render it an attractive candidate for these applications. The article also explores obstacles and potential future paths for advancing biomaterials made with PR, including synthesis modifications, characterisation techniques, and in vivo evaluation of biocompatibility and efficacy. Overall, as an emerging research topic, this review emphasises the potential of PR as a promising biomaterial for various biomedical applications and provides insights into the contemporary state of research and prospective directions for investigation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.