Renal denervation restores the baroreflex control of renal sympathetic nerve activity and heart rate in Wistar-Kyoto rats with cisplatin-induced renal failure

Khan SA 1 , Sattar MA , Rathore HA , Abdulla MH , Ud Din Ahmad F , Ahmad A Show all authors , Afzal S , Abdullah NA , Johns EJ

Affiliations 

  • 1 Department of Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
Acta Physiol (Oxf), 2014 Mar;210(3):690-700.
PMID: 24438102 DOI: 10.1111/apha.12237

Abstract

There is evidence that in chronic renal failure, the sympathetic nervous system is activated. This study investigated the role of the renal innervation in suppressing high- and low-pressure baroreflex control of renal sympathetic nerve activity and heart rate in cisplatin-induced renal failure.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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