The Effects of selenium supplementation on lipid profile in adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Saadh MJ 1 , Khaleel AQ 2 , Merza MS 3 , Hassan H 4 , Tomar BS 5 , Singh M 6 Show all authors , Kumar AV 7 , Hasaanzadeh S 8

Affiliations 

  • 1 Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan
  • 2 Department of Medical Instruments Engineering, Al-Maarif University College, Al ‎Anbar, 31001, Iraq. Electronic address: m86242994@gmail.com
  • 3 Prosthetic Dental Techniques Department, Al-Mustaqbal University College, Babylon, 51001, ‎Iraq
  • 4 Management and Science University, Shah Alam, Selangor, Malaysia
  • 5 Institute of Pediatric Gastroenterology and Hepatology, National Institute of Medical Sciences, ‎NIMS University Rajasthan, Jaipur, India
  • 6 Department of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of ‎Colleges-Jhanjeri, Mohali140307, Punjab, India
  • 7 Department of Mechanical Engineering, Raghu Engineering College, Vishakhapatnam - 531162, Andhra Pradesh, India
  • 8 Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: shirinhasanzadeh564@gmail.com
Prostaglandins Other Lipid Mediat, 2024 Sep 09.
PMID: 39260819 DOI: 10.1016/j.prostaglandins.2024.106901

Abstract

INTRODUCTION: Dyslipidemia with a considerable progression rate is a primary risk factor for CVDs if left untreated. Dietary interventions have explored the health influences of selenium on lipid profiles in adults, yet the findings remain contentious. This study seeks to determine if selenium supplementation can positively modify the lipid profile (total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL), and high-density lipoprotein cholesterol (HDL-C) in adults.

METHODS: Using predefined keywords, we searched online databases, including Scopus, PubMed, Web of Science Core Collection, and Google Scholar, for relevant studies published from inception through July 2024. A random-effects meta-analysis was then employed to pool the weighted mean differences (WMD) and 95% CI for outcomes assessed by a minimum of three studies.

RESULTS: Initially 1,205 studies were obtained out of which 25 RCTs were decided to be included for further analyses. Selenium supplementation reduced VLDL (WMD: -1.53; 95% CI: -2.86, -0.20), but did not change TG (WMD: 1.12; 95% CI: -4.51, 6.74), TC (WMD: -2.25; 95% CI: -6.80, 2.29), LDL-C (WMD: 1.60; 95% CI: -4.26, 7.46), and HDL-C levels (WMD: 0.98; 95% CI: - 0.02, 1.98).

CONCLUSION: Our study showed significantly reduced VLDL but limited effects were observed in other lipid indexes. More extensive RCTs are required globally to achieve a holistic comprehension of the connection between selenium and lipid profile.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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