Upregulated PCAT-1 predicts poor prognosis and reduced immune cell infiltration in head and neck squamous cell carcinoma through the miR-145-5p / FSCN-1 axis

Pirhoushiaran M 1 , Heidarzadehpilehrood R 2 , Mokhtarinejad M 1 , Hesami S 3 , Rezaei N 4 , Farahani AS 5

Affiliations 

  • 1 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  • 2 Department of Obstetrics & Gynaecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
  • 3 Medical Genetic Ward, Faculty of Medicine, Imam Khomeini Hospital Complex, IKHC, Tehran University of Medical Sciences, Tehran, Iran
  • 4 Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  • 5 Medical Genetic Ward, Faculty of Medicine, Imam Khomeini Hospital Complex, IKHC, Tehran University of Medical Sciences, Tehran, Iran. shakooria@tums.ac.ir
Mol Biol Rep, 2025 Jan 13;52(1):121.
PMID: 39806246 DOI: 10.1007/s11033-024-10208-1

Abstract

BACKGROUND: LncRNA PCAT-1 is known to promote cancer proliferation, invasion, and metastasis. However, its significance in HNSCC is not fully understood. This research investigates how the PCAT-1 / miR-145-5p / FSCN-1 axis promote HNSCC.

METHODS AND RESULTS: We analyzed the gene expression patterns on 238 fresh-frozen samples, comparing tumors with their normal adjacent tissues (NATs). HNSCC samples showed higher PCAT-1 and FSCN-1 expression compared to NATs (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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