Impact of cyclolinopeptide (linusorb) on oxidative stability of hot-pressed flaxseed oil and their interaction with phospholipid

Yu JH 1 , Zhang SR 1 , Du Y 1 , Deng DJ 1 , Zhang YK 1 , Li JL 1 Show all authors , Hu LJ 2 , Chen W 3 , Yue X 2 , Wang Y 1 , Chen J 4 , Cai ZZ 5

Affiliations 

  • 1 China-Malaysia Belt and Road Joint Laboratory on Oil Processing and Safety, Jinan University, P.R. China; Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, P.R. China
  • 2 State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China
  • 3 Perfect Life Science Research Institute (PLSRI), Perfect (GuangDong) Co., Ltd., Zhongshan 528402, China
  • 4 China-Malaysia Belt and Road Joint Laboratory on Oil Processing and Safety, Jinan University, P.R. China; Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, P.R. China. Electronic address: chenjiazi@jnu.edu.cn
  • 5 China-Malaysia Belt and Road Joint Laboratory on Oil Processing and Safety, Jinan University, P.R. China; Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, P.R. China. Electronic address: caizz@jnu.edu.cn
Food Chem, 2025 Mar 28;482:144110.
PMID: 40184739 DOI: 10.1016/j.foodchem.2025.144110

Abstract

This study examines the antioxidant capacity of linusorb (LOs) and their interaction with phospholipids (PLs) in hot-pressed flaxseed oil (HO), which is valued for its enhanced oxidative stability in Northwest China. Utilizing antioxidant assays and molecular simulations, the research aims to: 1) Assess oxidation indices to identify optimal roasting conditions and monitor LOs during the oxidation of HO, triacylglycerol (TAG), and TAG + LOs; 2) Analyze the oxidation kinetics of crude LOs (cLOs) from cold-pressed oil (CO) and LOs (hLOs) from HO in the presence of PLs; and 3) Molecular dynamics simulations to explore the interactions between PLs and LOs. The findings indicate that HO exhibits superior oxidative stability due to a higher concentration of LOs and PLs, with altered the antioxidative behavior of LOs. Simulation suggests that PLs can bind to LOs, facilitating their migration to the water-oil interface and enhancing their antioxidant effects.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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