BACKGROUND: People with obesity poses a threat for various non-communicable diseases (NCDs). Combining time-restricted feeding (TRF) with calorie restriction has been demonstrated to improve insulin sensitivity, decrease BMI and improved lipid profile.
OBJECTIVES: The novel objective of this study is to examine the effects of TRF with low carbohydrate and high protein and fat (LCHPF) diet on control and management of body weight, blood sugar and good cholesterol.
METHODOLOGY: This retrospective cohort study was performed at Clinixero in Kuala Lumpur between February 2021 and August 2023. In an open-label trial, all participants were assigned to one of two intervention groups with varying intervention durations (3 months or 6 months). Three month intervention group consists of Phase 1 TRF of 1.5 months (7 weeks) of a 16:8 h fasting-to-feeding ratio followed by another 1.5 months (7 weeks) of a 23:1 h ratio, whereas in six month intervention group phase 1 TRF comprises 3 months (13 weeks) of a 16:8 h fasting-to-feeding ratio followed by another 3 months (13 weeks) of a 23:1 h ratio. Individual BMI was measured along with fasting blood glucose, HbA1c and lipid profile before and after intervention.
RESULTS: After a 3-month TRF with LCHPF diet, the mean BMI decreased, although this difference was not statistically significant (p = 0.0572). However, after 6 months BMI was decreased significantly (p
* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.