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Does oral lansoprazole really reduce gastric acidity in VLBW premature neonates?

Tham SY 1 , Rogers IM 2 , Samuel KF 3 , Singh A 4 , Ong KK 5

Affiliations 

  • 1 Tham Sock Ying. Faculty of Medicine, AIMST University, Batu 3 Vz, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia.
  • 2 Ian Munro Rogers. Faculty of Medicine, AIMST University, Batu 3 ½, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia. irogers2000@hotmail.com
  • 3 Samuel K F. Neonatal Intensive Care Unit, Sultan Abdul Halim Hospital, Sungai Petani, Kedah, Malaysia.
  • 4 Singh A. Faculty of Medicine, AIMST University, Batu 3 ½, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia.
  • 5 Ong King Kok. Faculty of Medicine, AIMST University, Batu 3 ½, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia.
Med J Malaysia, 2012 Jun;67(3):284-8.
PMID: 23082418 MyJurnal

Abstract

Premature neonates of very low birth weight (VLBW) whose treatment required the use of naso-gastric tube feeding were investigated. 10 infants suspected of having GERD (gastroesophageal reflux) received oral lansoprazole therapy by tube administration. 9 other infants formed a control group. In the treated group a fasting pH was determined before treatment and again after 7 days treatment. The control group was similarly assessed at an interval of 7 days. Despite acid reduction, the post-treatment pH mean of 1.31 would continue to pose a threat to the esophageal mucosa. The physiology of neonatal acid secretion is discussed to explain these findings.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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