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Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper

Deraman MA 1 , Abdul Hafidz MI 2 , Lawenko RM 3 , Ma ZF 1 , Wong MS 1 , Coyle C 4 Show all authors , Lee YY 1

Affiliations 

  • 1 School of Medical Sciences, Universiti Sains Malaysia, Kota Bahru, Malaysia
  • 2 Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia
  • 3 De La Salle Health Sciences Institute, Dasmarinas, Philippines
  • 4 Reckitt Benckiser, Slough, UK
Aliment Pharmacol Ther, 2020 06;51(11):1014-1021.
PMID: 32343001 DOI: 10.1111/apt.15746

Abstract

BACKGROUND: Late-night supper increases the risk of postprandial reflux from the acid pocket especially in obesity. An alginate-based, raft-forming medication may be useful for obese patients with GERD.

AIMS: To compare the efficacy of Gaviscon Advance (Reckitt Benckiser, UK) and a non-alginate antacid in post-supper suppression of the acid pocket and post-prandial reflux among obese participants.

METHODS: Participants underwent 48 h wireless and probe-based pH-metry recording of the acid pocket and lower oesophagus, respectively, and were randomised to single post-supper (10 pm) dose of either Gaviscon Advance or a non-alginate antacid on the second night. Primary outcomes were suppression of median pH of acid pocket and lower oesophagus, measured every 10-minutes post-supper for 1 h. Secondary outcomes were suppression of % time pH 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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