Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides

Shimokawa Y 1 , Akao Y , Hirasawa Y , Awang K , Hadi AH , Sato S Show all authors , Aoyama C , Takeo J , Shiro M , Morita H

Affiliations 

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan
J Nat Prod, 2010 Apr 23;73(4):763-7.
PMID: 20192242 DOI: 10.1021/np9007987

Abstract

Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 1-4 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na(+)-glucose transporters (SGLT-1 and SGLT-2).

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