Chisomicines A-C, limonoids from Chisocheton ceramicus

Najmuldeen IA 1 , Hadi AH , Awang K , Mohamad K , Ketuly KA , Mukhtar MR Show all authors , Chong SL , Chan G , Nafiah MA , Weng NS , Shirota O , Hosoya T , Nugroho AE , Morita H

Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2011 May 27;74(5):1313-7.
PMID: 21428417 DOI: 10.1021/np200013g

Abstract

Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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