Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Caillaud A 1 , de la Iglesia P , Campàs M , Elandaloussi L , Fernández M , Mohammad-Noor N Show all authors , Andree K , Diogène J

Affiliations 

  • 1 IRTA, Ctra. Poble Nou, km. 5.5, 43540 Sant Carles de la Ràpita, Spain
Toxicon, 2010 Feb-Mar;55(2-3):633-7.
PMID: 19631680 DOI: 10.1016/j.toxicon.2009.07.016

Abstract

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.

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