Affiliations 

  • 1 Cancer Research Initiatives Foundation (CARIF), Outpatient Centre, Subang Jaya Medical Centre, Selangor, Malaysia
PLoS ONE, 2008;3(4):e2024.
PMID: 18431501 DOI: 10.1371/journal.pone.0002024

Abstract

BACKGROUND: In Asia, breast cancer is characterised by an early age of onset: In Malaysia, approximately 50% of cases occur in women under the age of 50 years. A proportion of these cases may be attributable, at least in part, to genetic components, but to date, the contribution of genetic components to breast cancer in many of Malaysia's ethnic groups has not been well-characterised.
METHODOLOGY: Given that hereditary breast carcinoma is primarily due to germline mutations in one of two breast cancer susceptibility genes, BRCA1 and BRCA2, we have characterised the spectrum of BRCA mutations in a cohort of 37 individuals with early-onset disease (

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.