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Unbalanced chromosomal translocation: a cause of recurrent spontaneous abortion

Zarina AL 1 , Jamil MA 2 , Ng SP 2 , Rohana J 3 , Yong SC 3 , Salwati S 4 Show all authors , Boo NY 3

Affiliations 

  • 1 Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur
  • 2 Department of Obstetrics & Gynaecology Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur
  • 3 Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur
  • 4 Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur
Med J Malaysia, 2006 Jun;61(2):260-2.
PMID: 16898328 MyJurnal

Abstract

Recurrent spontaneous abortion, defined as three consecutive abortions, occurs in approximately 1% to 2% of couples. Although the cause is unknown in up to 50% of cases, about 5% of these couples are found to be a balanced translocation carrier. We report a case in which the mother was identified to be a translocation carrier following the birth of a baby with multiple congenital abnormalities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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