Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice

Jabbarzare M 1 , Chin VK 2 , Talib H 3 , Yam MF 4 , Adam SK 1 , Hassan H 1 Show all authors , Abdul Majid R 5 , Mat Taib CN 1 , Mohd Moklas MA 1 , Taufik Hidayat M 1 , Mohd Sidek H 6 , Basir R 1

Affiliations 

  • 1 Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
  • 2 Dept. of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
  • 3 Dept. of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
  • 4 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 5 Dept. of Medical Microbiology and Parasitology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
  • 6 School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Malaysia
Iran J Parasitol, 2015 Jul-Sep;10(3):389-401.
PMID: 26622294

Abstract

Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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