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Familial hemophagocytic lymphohistiocytosis in two brothers

Gan GG 1 , Eow GI 2 , Teh A 3 , Ng SC 4 , Sangkar JV 5

Affiliations 

  • 1 G G Gan, MRCP. Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur
  • 2 G I Eow, MPath. Department of Pathology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur
  • 3 A Teh, FRCP. Hematology Unit, Subang Jaya Medical Centre, Subang Jaya
  • 4 S C Ng, FRCP. Hematology Unit, Subang Jaya Medical Centre, Subang Jaya
  • 5 J V Sangkar, MRCP. Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur
Med J Malaysia, 2004 Mar;59(1):100-2.
PMID: 15535343

Abstract

Familial hemophagocytic lymphohistiocytosis is a disorder which presents with fever, pancytopenia, liver dysfunction and also an increase in non-malignant histiocytes with prominent hemophagocytosis in various organs. It is usually difficult to distinguish from other hemophagocytic syndrome in the absence of family history. It rarely manifests in adults. Chemotherapy is usually indicated. Here, we report the occurrence of this disorder in two brothers in their twenties.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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