Affiliations 

  • 1 Tissue Culture Engineering Laboratory, Universiti Teknologi Malaysia (UTM), Malaysia
  • 2 College of Medicine, Hawler Medical University, Erbil, Iraq
  • 3 Department of Biochemistry, Faculty of Sciences, Universiti Teknologi Malaysia (UTM), Malaysia
  • 4 Institute of Bio-products Development, Universiti Teknologi Malaysia (UTM), Malaysia
Planta Med, 2016 Jan;82(1-2):32-45.
PMID: 26550791 DOI: 10.1055/s-0035-1558086

Abstract

Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.