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Progressive septal and palatal perforation secondary to intranasal cocaine abuse

Gendeh BS 1 , Ferguson BJ 2 , Johnson JT 3 , Kapadia S 4

Affiliations 

  • 1 B S Gendeh, MS (ORL-HNS),Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Hospital National University of Malaysia, Kuala Lumpur, Malaysia
  • 2 B J Ferguson, MD, FACS. Department of Otolaryngology, The Eye and Ear Institute, Suite 500, 200 Lothrop Street, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
  • 3 J T Johnson, MD, FACS. Department of Otolaryngology, The Eye and Ear Institute, Suite 500, 200 Lothrop Street, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
  • 4 S Kapadia, MD, FACPath. Department of Pathology, Presbyterian Hospital, 200 Lothrop Street, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Med J Malaysia, 1998 Dec;53(4):435-8.
PMID: 10971991

Abstract

Septal perforation from intranasal cocaine abuse is well recognised. We present a case of progressive septal as well as palatal perforation. Progression from septal perforation to palatal perforation occurred after cessation of intranasal cocaine abuse. This patient had a weakly positive cytoplasmic antineutrophilic cytoplasmic antibody (C-ANCA) but no histologic evidence of Wegener's Granulomatosis. The differential diagnosis for septal and palatal perforation is reviewed. This case represents the fifth reported case of palatal perforation secondary to cocaine abuse in the literature, and the second associated with positive C-ANCA.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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