Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocininduced
diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100,
200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats
treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly.
For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200
and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as
well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence
of antihyperglycemic properties from the reduction of the BGL in diabetic rats.