Laboratory-bred females of Culex quinquefasciatus, Aedes aegypti and Aedes
albopictus from the insectarium, Unit of Medical Entomology, Institute for Medical Research
were used in the experiment. The late third stage of the F0 larvae which survived the high
selection pressure of malathion, permethrin and temephos were reared and colonies were
established from adults that emerged. Cx. quinquefasciatus larvae were subjected to selection
by malathion and permethrin for 40 generations, Ae.aegypti larvae to malathion, permethrin
and temephos for 32 generations and Ae.albopictus larvae were selected against malathion
and permethrin for 32 generations and 20 generations against temephos.. The rate of resistance
development was measured by LC50 value . Cx. quinquefasciatus larvae developed higher
resistance to malathion and permethrin compared to Ae.aegypti and Ae.albopictus. On the
whole, permethrin resistance developed at a faster rate than malathion and temephos.