Health-related quality of life (HRQoL) assessment is important in healthcare outcomes. This study aimed to determine the feasibility, reliability and validity of the Malay McGill Quality of Life Questionnaire — Cardiff Short Form (MMQOL-CSF) in advanced cancer population. Patients either completed the MMQOL-CSF alone or in addition to its long version. The study recruited 116 participants (average age = 44 years old). On average, MMQOL-CSF was completed in 5.4 minutes. Most domains showed evidence of reliability (Croanbach’s $\b{\alpha}$= 076-092). Correlation with its long version was moderate to strong ($r_s$ = 0.54-087). The MMQOL-CSF was a feasible, reliable and valid HRQ0L instrument in this population.