HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Tan LK 1 , Mohd-Farid B 2 , Salsabil S 2 , Heselynn H 3 , Wahinuddin S 4 , Lau IS 5 Show all authors , Gun SC 6 , Nor-Suhaila S 3 , Eashwary M 3 , Mohd-Shahrir MS 7 , Ainon MM 8 , Azmillah R 5 , Muhaini O 9 , Shahnaz M 2 , Too CL 10

Affiliations 

  • 1 Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia. Electronic address: tanlk@imr.gov.my
  • 2 Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 3 Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia
  • 4 Department of Medicine, Hospital Raja Perempuan Bainun, Ipoh, Perak, Malaysia; Universiti Kuala Lumpur, Royal College of Medicine Perak, No 3, Jalan Greentown, 30450 Ipoh, Perak, Malaysia
  • 5 Department of Medicine, Hospital Selayang, Selangor, Malaysia
  • 6 Department of Medicine, Hospital Tunku Ja'afar Seremban, Negeri Sembilan, Malaysia
  • 7 Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Selangor, Malaysia
  • 8 Department of Medicine, Tengku Ampuan Afzan Hospital, Kuantan, Pahang, Malaysia
  • 9 Department of Medicine, Hospital Raja Perempuan Bainun, Ipoh, Perak, Malaysia
  • 10 Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia; Rheumatology Unit, Department of Medicine, CMM L8:O4, Karolinska University Hospital and Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address: toocl@imr.gov.my
Hum Immunol, 2016 Oct;77(10):818-819.
PMID: 27370684 DOI: 10.1016/j.humimm.2016.06.022

Abstract

A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p<0.0001), -B (p<0.0001), -DRB1 (p<0.0001) and -DQB1 (p<0.01) loci. Minor deviations from HWEP were detected for HLA-C (p=0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015).

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