HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia

Nurul-Aain AF 1 , Tan LK 2 , Heselynn H 3 , Nor-Shuhaila S 3 , Eashwary M 3 , Wahinuddin S 4 Show all authors , Lau IS 5 , Gun SC 6 , Mohd-Shahrir MS 7 , Ainon MM 8 , Azmillah R 5 , Muhaini O 9 , Shahnaz M 2 , Too CL 10

Affiliations 

  • 1 Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. Electronic address: nurulaain.fauzi@moh.gov.my
  • 2 Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia
  • 3 Department of Medicine, Putrajaya Hospital, Ministry of Health Malaysia, Putrajaya, Malaysia
  • 4 Department of Medicine, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia, Perak, Malaysia; Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia
  • 5 Department of Medicine, Selayang Hospital, Ministry of Health Malaysia, Selayang, Selangor, Malaysia
  • 6 Department of Medicine, Hospital Tuanku Ja'afar Seremban, Ministry of Health Malaysia, Seremban, Negeri Sembilan, Malaysia
  • 7 Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia
  • 8 Department of Medicine, Tengku Ampuan Afzan Hospital, Ministry of Health Malaysia, Kuantan, Pahang, Malaysia
  • 9 Department of Medicine, Taiping Hospital, Ministry of Health Malaysia, Perak, Malaysia
  • 10 Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia; Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address: toocl@moh.gov.my
Hum Immunol, 2020 Jun;81(6):263-264.
PMID: 32312605 DOI: 10.1016/j.humimm.2020.04.004

Abstract

A total of 271 Southeast Asia Indians from Peninsular Malaysia were genotyped for HLA-A, -B, -C, -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, HLA-B and HLA-DQB1 was in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from the HWEP for HLA-A (p 

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