HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 194 Southeast Asia Chinese from Peninsular Malaysia

Too CL 1 , Tan LK 2 , Heselynn H 3 , Nor-Shuhaila S 3 , Eashwary M 3 , Wahinuddin S 4 Show all authors , Lau IS 5 , Gun SC 6 , Mohd-Shahrir MS 7 , Ainon MM 8 , Azmillah R 5 , Muhaini O 9 , Shahnaz M 2

Affiliations 

  • 1 Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Kuala Lumpur, Malaysia; Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address: toocl@imr.gov.my
  • 2 Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Kuala Lumpur, Malaysia
  • 3 Department of Medicine, Putrajaya Hospital, Ministry of Health Malaysia, Putrajaya, Malaysia
  • 4 Department of Medicine, Hospital Raja Perempuan Bainun, Ministry of Health Malaysia, Perak, Malaysia; Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia
  • 5 Department of Medicine, Selayang Hospital, Ministry of Health Malaysia, Selayang, Selangor, Malaysia
  • 6 Department of Medicine, Hospital Tuanku Ja'afar Seremban, Ministry of Health Malaysia, Seremban, Negeri Sembilan, Malaysia
  • 7 Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia
  • 8 Department of Medicine, Tengku Ampuan Afzan Hospital, Ministry of Health Malaysia, Kuantan, Pahang, Malaysia
  • 9 Department of Medicine, Taiping Hospital, Ministry of Health Malaysia, Perak, Malaysia
Hum Immunol, 2019 Nov;80(11):906-907.
PMID: 31558331 DOI: 10.1016/j.humimm.2019.09.005

Abstract

A total of 194 Southeast Asia Chinese from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, the HLA-B, HLA-DRB1 and HLA-DQB1 were in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from HWEP in HLA-A (p 

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