Distribution of HLA-A, -B and -DRB1 alleles in the Kensiu and Semai Orang Asli sub-groups in Peninsular Malaysia

Tasnim AR; Allia S; Edinur HA; Panneerchelvam S; Zafarina Z; Norazmi MN

doi:10.1016/j.humimm.2016.06.009

Distribution of HLA-A, -B and -DRB1 alleles in the Kensiu and Semai Orang Asli sub-groups in Peninsular Malaysia

Tasnim AR ¹ , Allia S ¹ , Edinur HA ¹ , Panneerchelvam S ¹ , Zafarina Z ² , Norazmi MN ³

Affiliations

¹ Human Identification Unit, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
² Human Identification Unit, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Analytical Biochemistry Research Centre, Universiti Sains Malaysia, 11800 USM Penang, Malaysia
³ Human Identification Unit, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: norazmimn@usm.my

Hum Immunol, 2016 Aug;77(8):618-619.

PMID: 27296326 DOI: 10.1016/j.humimm.2016.06.009

Abstract

The earliest settlers in Peninsular Malaysia are the Orang Asli population, namely Semang, Senoi and Proto Malays. In the present study, we typed the HLA-A, -B and -DRB1 loci of the Kensiu and Semai Orang Asli sub-groups. Sequence-based HLA typing was performed on 59 individuals from two Orang Asli sub-groups. A total of 11, 18 and 14 HLA-A, -B and -DRB1 alleles were identified, respectively. These data are available in the Allele Frequencies Net Database under the population name "Malaysia Kedah Kensiu" and "Malaysia Pahang Semai".

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.