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Comparison of cytotoxicity between extracts of Clinacanthus nutans (Burm. f.) Lindau leaves from different locations and the induction of apoptosis by the crude methanol leaf extract in D24 human melanoma cells

Fong SY 1 , Piva T 2 , Dekiwadia C 3 , Urban S 4 , Huynh T 5

Affiliations 

  • 1 Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia. siatyee@ums.edu.my
  • 2 School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, 3083, VIC, Australia
  • 3 RMIT Microscopy and Microanalysis Facility, RMIT University, GPO Box 2476, Melbourne, 3001, VIC, Australia
  • 4 School of Science, RMIT University, GPO Box 2476, Melbourne, 3001, VIC, Australia
  • 5 School of Science, RMIT University, PO Box 71, Bundoora, 3083, VIC, Australia
BMC Complement Altern Med, 2016 Sep 20;16:368.
PMID: 27646974 DOI: 10.1186/s12906-016-1348-x

Abstract

Clinacanthus nutans (Burm. f.) Lindau leaves are widely used by cancer patients and the leaf extracts possess cytotoxic and antiproliferative effects on several human cancer cell lines. However, the effect of C. nutans leaf extract on human melanoma, which is the least common but most fatal form of skin cancer and one of the most common cancers diagnosed in both sexes worldwide, is unknown. There is also limited information on whether the bioactivity of extracts differs between C. nutans leaves grown in different geographical locations with varying environmental conditions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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