Affiliations 

  • 1 a Pharmaceutics Division , Sri Padmavathi School of Pharmacy , Tiruchanoor, Tirupati , India
  • 2 b Pharmaceutics Division , PES College of Pharmacy , Bangalore , India
  • 3 c School of Pharmacy , The University of Nottingham Malaysia Campus, Jalan Broga, Semenyih , Selangor , Malaysia
Artif Cells Nanomed Biotechnol, 2017 Dec;45(8):1539-1547.
PMID: 27887040 DOI: 10.1080/21691401.2016.1260579

Abstract

Research was aimed on microemulsion-based hydrogel for voriconazole. Oleic acid and isopropyl myristate as lipid phases; tween 20: tween 80 as surfactants and PEG600 as cosurfactant were selected to formulate voriconazole microemulsions. The promising microemulsions in terms of zeta potential, pH, viscosity, and drug release were selected and developed into hydrogels using carbopol 934. Resulting microemulsion-based hydrogel (MBH) of voriconazole were evaluated for in vitro diffusion and ex vivo permeation. Antifungal potentials of MBH were assessed against selected fungal strains. Optimal MBH formulations, O6 and O8 had displayed their antifungal potentials with enlarged zone of inhibition against selected fungal strains.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.