Micro-anatomical changes in major blood vessel caused by dengue virus (serotype 2) infection

Priya SP 1 , Sakinah S 1 , Ling MP 2 , Chee HY 1 , Higuchi A 3 , Hamat RA 1 Show all authors , Neela VK 1 , Alarfaj AA 4 , Munusamy MA 4 , Hatamleh AA 4 , Al-Sabri AE 4 , Abdulaziz Al-Suwailem IA 4 , Rajan M 5 , Benelli G 6 , Marlina 7 , Kumar SS 8

Affiliations 

  • 1 Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
  • 2 Department of Biomedical Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
  • 3 Department of Chemical and Materials Engineering, National Central University, Jhong-li, Taoyuan, 32001 Taiwan; Department of Reproduction, National Research Institute for Child Health and Development, Tokyo, 157-8535, Japan; Department of Botany and Microbiology, King Saud University, Riyadh, 11451, Saudi Arabia
  • 4 Department of Botany and Microbiology, King Saud University, Riyadh, 11451, Saudi Arabia
  • 5 Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-21, Tamil Nadu, India
  • 6 Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy
  • 7 Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatera, Indonesia
  • 8 Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Innoscience Research, Kuala Lumpur, Malaysia. Electronic address: sureshkudsc@gmail.com
Acta Trop, 2017 Jul;171:213-219.
PMID: 28427958 DOI: 10.1016/j.actatropica.2017.04.010

Abstract

Dengue virus (DENV) has emerged as a major economic concern in developing countries, with 2.5 billion people believed to be at risk. Vascular endothelial cells (ECs) lining the circulatory system from heart to end vessels perform crucial functions in the human body, by aiding gas exchange in lungs, gaseous, nutritional and its waste exchange in all tissues, including the blood brain barrier, filtration of fluid in the glomeruli, neutrophil recruitment, hormone trafficking, as well as maintenance of blood vessel tone and hemostasis. These functions can be deregulated during DENV infection. In this study, BALB/c mice infected with DENV serotype 2 were analyzed histologically for changes in major blood vessels in response to DENV infection. In the uninfected mouse model, blood vessels showed normal architecture with intact endothelial monolayer, tunica media, and tunica adventitia. In the infected mouse model, DENV distorted the endothelium lining and disturbed the smooth muscle, elastic laminae and their supporting tissues causing vascular structural disarrangement. This may explain the severe pathological illness in DENV-infected individuals. The overall DENV-induced damages on the endothelial and it's supporting tissues and the dysregulated immune reactions initiated by the host were discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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