Affiliations 

  • 1 Department of Psychiatry, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia
  • 2 Department of Psychiatry and Mental Health, Hospital Kuala Lumpur, Kuala Lumpur, Wilayah Persekutuan, Malaysia
  • 3 Department of Psychiatry, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
  • 4 Department of Psychiatry, University Putra Malaysia, Serdang, Selangor, Malaysia
BMJ Case Rep, 2017 Jul 27;2017.
PMID: 28754761 DOI: 10.1136/bcr-2017-221048

Abstract

A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due to treatment resistance, adherence and functionality were poor and there was still persistent drug use. As a result, a long acting injectable adjunct was commenced, but only minimal effects were observed. However after initiation of directly observed treatment of clozapine with methadone, there has been functional and clinical response and drug use has ceased.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.