Affiliations 

  • 1 Department of Mechanical & Industrial Engineering, Ryerson University, Toronto M5B 2K3, Ontario, Canada
  • 2 Department of Chemistry and Biology, Ryerson University, Toronto M5B 2K3, Ontario, Canada
  • 3 St. Michael's Hospital, Toronto M5B 1W8, Ontario, Canada
  • 4 Oakville Trafalgar Memorial Hospital, Oakville L6J 3L7, Ontario, Canada
Heliyon, 2017 Oct;3(10):e00420.
PMID: 29034340 DOI: 10.1016/j.heliyon.2017.e00420

Abstract

In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn(2+)), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.