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Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

Nguyen TA 1 , Pham T 2 , Vu HTT 2 , Nguyen TX 2 , Vu TT 2 , Nguyen BTT 2 Show all authors , Nguyen NQ 2 , Nguyen BT 2 , Nguyen BT 2 , Nguyen TN 2 , Phan SV 2 , Nguyen AT 2 , Pham TL 3 , Dang HT 1 , Kalisch-Ellett L 1 , Gillam M 1 , Pratt N 1 , Qiang S 4 , Wang H 4 , Kanjanarach T 5 , Hassali MAA 6 , Babar ZU 7 , Razak AA 8 , Chinwong D 9 , Roughead EE 1

Affiliations 

  • 1 1 Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia
  • 2 2 National Geriatric Hospital of Vietnam, Hanoi, Vietnam
  • 3 3 Hanoi Medical University and Ministry of Health of Vietnam, Hanoi, Vietnam
  • 4 4 Center for Health Management and Policy, School of Health Care Management, Shandong University, Jinan, China
  • 5 5 Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
  • 6 6 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 7 7 Department of Pharmacy, University of Huddersfield, England, United Kingdom
  • 8 8 Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 9 9 Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
Am J Alzheimers Dis Other Demen, 2018 Nov;33(7):423-432.
PMID: 29642720 DOI: 10.1177/1533317518768999

Abstract

This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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