• 1 Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Japan.
  • 2 Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • 3 Department of Cardiology, New Tokyo Hospital, Matsudo, Japan
  • 4 Department of Plastic Surgery, Yao Tokushukai General Hospital, Yao, Japan
  • 5 Division of Cardiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan
  • 6 Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea
  • 7 Department of Cardiology, Busan Veterans Hospital, Busan, South Korea
  • 8 Department of Orthopedic Surgery, Busan Veterans Hospital, Busan, South Korea
  • 9 Department of Cardiology, Rakuwakai Otowa Hospital, Kyoto, Japan
  • 10 Department of Cardiology, Kyoto Second Red Cross Hospital, Kyoto, Japan
  • 11 Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan
  • 12 Department of Radiology, Nara Medical University, Kashihara, Japan
  • 13 Division of Vascular Surgery, Tokyo Saiseikai Central Hospital, Tokyo, Japan
  • 14 Department of Cardiology, Kishiwada Tokushukai Hospital, Kishiwada, Japan
  • 15 Department of Radiology, Tsuchiya General Hospital, Hiroshima, Japan
  • 16 Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong Kong
  • 17 Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
  • 18 Department of Vascular Surgery, Siriraj Hospital, Bangkok, Thailand
  • 19 Department of Vascular Surgery, Cardiac Vascular Sentral Kuala Lumpur, Kuala Lumpur, Malaysia
  • 20 Department of Vascular Surgery, Vascular and Interventional Centre Singapore, Mount Elizabeth Novena Specialist Centre, The Farrer Park Hospital, Singapore, Singapore
  • 21 Department of Vascular Surgery, Narayana Hrudayalaya and Mazumdar Shaw Medical Centre, Bengaluru, India
  • 22 Department of Plastic and Reconstructive Surgery, Osaka City University, Osaka, Japan
  • 23 Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Cardiovasc Interv Ther, 2018 Oct;33(4):297-312.
PMID: 29654408 DOI: 10.1007/s12928-018-0523-z


The burden of peripheral artery disease (PAD) and diabetes in Asia is projected to increase. Asia also has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world. Therefore, most Asian patients with PAD might have diabetic PAD or ESRD-related PAD. Given these pandemic conditions, critical limb ischemia (CLI) with diabetes or ESRD, the most advanced and challenging subset of PAD, is an emerging public health issue in Asian countries. Given that diabetic and ESRD-related CLI have complex pathophysiology that involve arterial insufficiency, bacterial infection, neuropathy, and foot deformity, a coordinated approach that involves endovascular therapy and wound care is vital. Recently, there is increasing interaction among cardiologists, vascular surgeons, radiologists, orthopedic surgeons, and plastic surgeons beyond specialty and country boundaries in Asia. This article is intended to share practical Asian multidisciplinary consensus statement on the collaboration between endovascular therapy and wound care for CLI.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.