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DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients

Zainal Abidin S 1 , Tan EL 2 , Chan SC 3 , Jaafar A 4 , Lee AX 5 , Abd Hamid MH 6 Show all authors , Abdul Murad NA 7 , Pakarul Razy NF 8 , Azmin S 9 , Ahmad Annuar A 10 , Lim SY 11 , Cheah PS 12 , Ling KH 13 , Mohamed Ibrahim N 14

Affiliations 

  • 1 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. shah.68000@gmail.com
  • 2 Department of Medicine, Universiti Kebangsaan Malaysia Medical Center, Bandar Tun Razak Cheras, 56000, Kuala Lumpur, Malaysia. drtanengliang@gmail.com
  • 3 Perdana University Graduate School of Medicine, Perdana University, 43400, Serdang, Selangor, Malaysia. soonchoyc@yahoo.com
  • 4 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. ameerah.jaafar@gmail.com
  • 5 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. libk201@hotmail.com
  • 6 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. medinoor89@gmail.com
  • 7 UKM Medical Molecular Biology Institute, UKM Medical Center, Jalan Ya'acob Latiff, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia. nor_azian@ppukm.ukm.edu.my
  • 8 UKM Medical Molecular Biology Institute, UKM Medical Center, Jalan Ya'acob Latiff, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia. nurmp89@yahoo.com
  • 9 Department of Medicine, Universiti Kebangsaan Malaysia Medical Center, Bandar Tun Razak Cheras, 56000, Kuala Lumpur, Malaysia. shahrulazmin@hotmail.com
  • 10 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. azlina_aa@um.edu.my
  • 11 Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. limshenyang@ymail.com
  • 12 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. cheahpikesee@upm.edu.my
  • 13 Neurobiology and Genetics Group, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. lkh@upm.edu.my
  • 14 Department of Medicine, Universiti Kebangsaan Malaysia Medical Center, Bandar Tun Razak Cheras, 56000, Kuala Lumpur, Malaysia. norlinah@ppukm.ukm.edu.my
BMC Neurol, 2015;15:59.
PMID: 25896831 DOI: 10.1186/s12883-015-0316-2

Abstract

Impulse control disorder (ICD) and behaviours (ICB) represent a group of behavioural disorders that have become increasingly recognised in Parkinson's disease (PD) patients who previously used dopaminergic medications, particularly dopamine agonists and levodopa. It has been suggested that these medications can lead to the development of ICB through the abnormal modulation of dopaminergic transmission and signalling in the mesocorticolimbic dopaminergic system. Several studies have reported an association between polymorphisms in the dopamine receptor (DRD) and N-methyl-D-aspartate 2B (GRIN2B) genes with the development of ICB in PD (PD-ICB) patients. Thus, this study aimed to investigate the association of selected polymorphisms within the DRD and GRIN2B genes with the development of ICB among PD patients using high resolution melt (HRM) analysis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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