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Full genome SNP-based phylogenetic analysis reveals the origin and global spread of Brucella melitensis

Tan KK 1 , Tan YC 2 , Chang LY 3 , Lee KW 4 , Nore SS 5 , Yee WY 6 Show all authors , Mat Isa MN 7 , Jafar FL 8 , Hoh CC 9 , AbuBakar S 10

Affiliations 

  • 1 Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603, Kuala Lumpur, Malaysia. kimkee@um.edu.my
  • 2 Codon Genomics S/B, No 26, Jalan Dutamas 7, Taman Dutamas, Balakong, 43200, Seri Kembangan, Selangor, Malaysia. yungchie@codongenomics.com
  • 3 Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603, Kuala Lumpur, Malaysia. changly@um.edu.my
  • 4 Codon Genomics S/B, No 26, Jalan Dutamas 7, Taman Dutamas, Balakong, 43200, Seri Kembangan, Selangor, Malaysia. kokwei.lee@codongenomics.com
  • 5 Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603, Kuala Lumpur, Malaysia. sitisarahnore@um.edu.my
  • 6 Codon Genomics S/B, No 26, Jalan Dutamas 7, Taman Dutamas, Balakong, 43200, Seri Kembangan, Selangor, Malaysia. sunny.yee@codongenomics.com
  • 7 Malaysia Genome Institute, Ministry of Science, Technology and Innovation, Jalan Bangi, 43000, Kajang, Selangor, Malaysia. emno72@gmail.com
  • 8 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. flela@um.edu.my
  • 9 Codon Genomics S/B, No 26, Jalan Dutamas 7, Taman Dutamas, Balakong, 43200, Seri Kembangan, Selangor, Malaysia. ivan.hoh@codongenomics.com
  • 10 Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603, Kuala Lumpur, Malaysia. sazaly@um.edu.my
BMC Genomics, 2015;16:93.
PMID: 25888205 DOI: 10.1186/s12864-015-1294-x

Abstract

Brucellosis is an important zoonotic disease that affects both humans and animals. We sequenced the full genome and characterised the genetic diversity of two Brucella melitensis isolates from Malaysia and the Philippines. In addition, we performed a comparative whole-genome single nucleotide polymorphism (SNP) analysis of B. melitensis strains collected from around the world, to investigate the potential origin and the history of the global spread of B. melitensis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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