• 1 Division of Clinical Dentistry, School of Dentistry, International Medical University, 57000 Kuala Lumpur, Malaysia
  • 2 School of Medicine and Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK
  • 3 Modern Dental College & Research Centre, Indore, Madhya Pradesh 45311, India
  • 4 Division of Oral Diagnostic and Surgical Sciences, School of Dentistry, International Medical University, 57000 Kuala Lumpur, Malaysia
  • 5 Faculty of Pharmacy, Lincoln University College, Petaling Jaya, Selangor, Kuala Lumpur 47301, Malaysia
  • 6 Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741 246, West Bengal, India
  • 7 Department of Pharmaceutical Technology, The International Medical University, Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia. Electronic address:
Drug Discov Today, 2019 01;24(1):85-98.
PMID: 30176358 DOI: 10.1016/j.drudis.2018.08.012


Maintenance of oral health is a major challenge in dentistry. Different materials have been used to treat various dental diseases, although treatment success is limited by features of the biomaterials used. To overcome these limitations, materials incorporated with nanoparticles (NPs) can be used in dental applications including endodontics, periodontics, tissue engineering, oral surgery, and imaging. The unique properties of NPs, including their surface:volume ratio, antibacterial action, physical, mechanical, and biological characteristics, and unique particle size have rendered them effective vehicles for dental applications. In this review, we provide insights into the various applications of NPs in dentistry, including their benefits, limitations, properties, actions and future potential.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.